Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Understanding the Difference Between L Glutamine and Glutathione: What You Need to Know Cymbiotika CYMBIOTIKA Tylenol and Glutathione: Myths Debunked As a naturopathic doctor and a mom, Tylenol is a hard no in my house and I want to explain why. , , Acetaminophen (Tylenol) is processed through the liver, and in that process it can lower Glutamine Vs Creatine: What Are The Differences